Existence of a Pool of T-Lymphocyte Colony-Forming Cells (T-CFC) in Human Bone Marrow and Their Place in the Differentiation
نویسندگان
چکیده
The existence and characteristics of bone marrow T-ceII progenitors have not yet been established in man. Several pieces of evidence such as the reconstitution of certain immunodeficiencies by bone marrow graft suggest that T-ceIl precursors are present in the bone marrow. We report the growth of T-ceII colonies from bone marrow populations using PHA-stimulated lymphocyte-conditioned medium containing T-ceIl growth factor (TCGF). Rosetting experiments and complement-dependent cytotoxicity assays with monoclonal antibodies indicate that the bone marrow T colony-forming cells (T-CFC) are E OKT 3and Ia + . i.e.. immature progenitors. The colonies derived
منابع مشابه
Existence of a pool of T-lymphocyte colony-forming cells (T-CFC) in human bone marrow and their place in the differentiation of the T-lymphocyte lineage.
The existence and characteristics of bone marrow T-cell progenitors have not yet been established in man. Several pieces of evidence such as the reconstitution of certain immunodeficiencies by bone marrow graft suggest that T-cell precursors are present in the bone marrow. We report the growth of T-cell colonies from bone marrow populations using PHA-stimulated lymphocyte-conditioned medium con...
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